Biochem/physiol Actions

Reversible: yes

Product does not compete with ATP.

Target IC₅₀: 24 nM, 18.4 nM, 30 nM, 2.7 nM, against MMP-1, MMP-3, MMp-7, and MMP-9, respectively

Cell permeable: yes

General description

A potent, reversible, broad-range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC₅₀ = 24 nM), MMP-3 (IC₅₀ = 18.4 nM), MMP-7 (IC₅₀ = 30 nM), and MMP-9 (IC₅₀ = 2.7 nM).

A potent, reversible, broad range inhibitor of matrix metalloproteinases. Inhibits MMP-1 (IC₅₀ = 24 nM), MMP-3 (IC₅₀ = 18.4 nM), MMP-7 (IC₅₀ = 30 nM), and MMP-9 (IC₅₀ = 2.7 nM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Pikul, S., et al. 1998. J. Med. Chem. 41, 3568.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Preparation Note

Requires vigorous vortexing for 60 seconds to completely solubilize the product.

Warning

Toxicity: Standard Handling (A)